FENTANYL EPIDEMIC IN U.S.
Ricky Rubin
Potent synthetic opioid 50-100x more potent than morphine.
Mu-selective opioid agonist to produce analgesia.
Hepatically metabolized via the CYP450 enzyme system (CYP3A4) with a 3-7 hour 1/2 life.
Illegally produced and laced in cocaine, heroin and pills, fentanyl has killed 100,000+ people in the U.S. within the last 12 months.